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KMID : 0648620130180020044
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Korean Journal of Nosocomial Infection Control
2013 Volume.18 No. 2 p.44 ~ p.50
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Trends in Antibiotic Use in a Single University Hospital
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Jun Kang-Il
Koo Hei-Lim
Kang Chang-Kyung
Kim Min-Jae
Chun Shin-Hye
Song Jung-Sook
Kim Hyang-Suk
Kim Nam-Joong
Kim Eui-Chong
Oh Myoung-Don
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Abstract
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Background: The aim of this study was to evaluate antibiotic consumption by adult patients at a single university hospital in Korea between 2001 and 2012.
Methods: We used the 2004 World Health Organization Anatomical Therapeutic Chemical Classification System definition of defined daily doses (DDD) per 1,000 patient-days to calculate the annual antibiotic consumption for 18 antibiotic groups. Chi-square linear-by-linear analysis was performed to evaluate antibiotic consumption trends for each group.
Results: Average annual antibiotic consumption during 2001-2012 was 644.6 DDD/1,000 patient-days (standard deviation, 33.3 DDD/1,000 patient-days). Although no statistically significant change was observed during the study period, consumption of first- and second-generation cephalosporins, and aminoglycosides was significantly decreased, while that of beta-lactam/beta-lactamase inhibitors, fourth-generation cephalosporins, carbapenem, glycopeptide, linezolid, colistin, and quinolone increased significantly.
Conclusion: The total amount of prescribed antibiotics did not change, but the use of broad-spectrum antibiotics increased during the study period.
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KEYWORD
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Anti-bacterial agents, University hospitals, Utilization
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